Working to combine our deep biologic knowledge with cutting-edge
research technology to accelerate the delivery of advancements in
Regulated cell death – apoptosis
Apoptosis is a form of regulated cell death, a natural process that eliminates damaged, unneeded or dangerous cells from the body.1 Through our deep knowledge of apoptosis and the role impaired apoptosis can play in the proliferation of cancer cells, we are advancing novel cancer research.
Novel tumor targeting
Antigens are markers on cells that can be used to specifically target cells that express the marker, including cancer cells, with therapeutic agents.4 The ideal antigen is present on cancer cells but not on normal cells. At AbbVie, we are leveraging our expertise across multiple technology platforms to identify novel antigens and research therapeutic approaches needed to target them.
- Cory S, Huang DCS, Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene. 2003;22:8590-8607.
- Cancercare.org. Understanding the Role of Immuno-Oncology in Treating Cancer- Immuno-Oncology. Retrieved from: https://www.cancercare.org/publications/285-understanding_the_role_of_immuno-oncology_in_treating_cancer. Accessed January 2019.
- Burger, JA, Ghia P, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009. 114:3367-3375
- Alatrash G, Crain, A, et al. Chapter 7 – Tumor-Associated Antigens. Immune Biologic Allogeneic Hematopoeitic Stem cell Transplantation. 2019(2):107-125.